BDBM25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870::US11851436, Compound BI-D1870

SMILES CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12

InChI Key InChIKey=DTEKTGDVSARYDS-UHFFFAOYSA-N

Data  32 IC50  4 Kd  1 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25017   

TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
University of Dundee

LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
University of Dundee

LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  18nMAssay Description:Inhibition of RSK3 (unknown origin) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK a substrate by [32P] gammaATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
University of Dundee

LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  13nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
University of Dundee

LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  18nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
University of Dundee

LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human RSK3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
University of Dundee

LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  18nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed